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Biostatistics people

- Rémi Servien, Chargé de Recherche INRA
- Pascal Bourdaud’hui, Assistant ingénieur INRA
- Didier Concordet, Professeur
- Peggy Gandia, Maître de Conférences des Universités et Praticien Hospitalier

Research interests

- Stochastic Modeling for Biology
- Population Pharmacokinetics and Pharmacodynamics
- Non Linear Models for Repeated Measurments Data (Longitudinal Data Sets)
- Non Linear Stochastic Inverse Problems
- Non Linear Mixed Effects Models
- Mixtures Models
- Deterministic and Stochastic Algorithms for Statistical Inference
- Non Parametric and Semi-Parametric Statistical Inference

Articles and preprints

-------- Publications 2014 --------


Articles
1.
D. CONCORDET and R.SERVIEN
Individual prediction regions for multivariate longitudinal data with small samples, Biometrics accepted (2014)
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2.
Misbach C, Lefebvre HP, Concordet D, Gouni V, Trehiou-Sechi E, Petit AM, Damoiseaux C, Leverrier A, Pouchelon JL, Chetboul V
Echocardiography and conventional Doppler examination in clinically healthy adult Cavalier King Charles Spaniels: Effect of body weight, age, and gender, and establishment of reference intervals, J Vet Cardiol accepted (2014)
3.
R. Servien, L. Mamy, Z. Li, V. Rossard, E. Latrille, F. Bessac, D. Patureau et P. Benoit
TyPol - a New Methodology for Organic Pollutants Clustering based on their Molecular Characteristics and Environmental Behavior, Chemosphere accepted (2014)
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4.
E. Di Bernardino, T. Laloë et R. Servien
Estimating covariate functions associated to multivariate risks : a level sets approach, Metrika accepted (2014)
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5.
Laffont CM, Vandemeulebroecke M, Concordet D
Multivariate Analysis of Longitudinal Ordinal Data with Mixed Effects Models, with Application to Clinical Outcomes in Osteoarthritis, JASA accepted (2014)

-------- Publications 2013 --------


Articles
1.
David I, Elsen JM, Concordet D
CLIP Test: a new fast, simple and powerful method to distinguish between linked or pleiotropic quantitative trait loci in linkage disequilibria analysis, Heredity (Edinb) 110(3):232-8 (2013)
2.
Leroy C, Conchou F, Layssol-Lamour C, Deviers A, Sautet J, Concordet D, Mogicato G
Reproducibility, Observer-Dependent Variability of Ultrasonographic Measurements of the Prostate in Healthy Intact Beagles, Anat Histol Embryol 45(5) 355-361 (2013)
3.
Reynolds BS, Chetboul V, Nguyen P, Testault I, Concordet DV, Carlos Sampedrano C, Elliott J, Trehiou-Sechi E, Abadie J, Biourge V, Lefebvre HP
Effects of dietary salt intake on renal function: a 2-year study in healthy aged cats, J Vet Intern Med 27(3):507-515 (2013)
4.
Pastor ML, Laffont CM, Gladieff L, Schmitt A, Chatelut E, Concordet D
Model-based approach to describe G-CSF effects in carboplatin-treated cancer patients, Pharm Res 30(11):2795-2807 (2013)
5.
Lefebvre HP, Ollivier E, Atkins CE, Combes B, Concordet D, Kaltsatos V, Baduel L
Safety of spironolactone in dogs with chronic heart failure because of degenerative valvular disease: a population-based, longitudinal study, J Vet Intern Med 27(5):1083-91 (2013)
6.
Braun JP, Concordet D, Geffré A, Bourges Abella N, Trumel C
Confidence intervals of reference limits in small reference sample groups, Vet Clin Pathol 42(3):395-8 (2013)
7.
Misbach C, Chetboul V, Concordet D, Gruet P, Speranza C, Hoffmann AC, Rocha A, Balouka D, Petit AM, Trehiou-Sechi E, Pouchelon JL, Lefebvre HP
Basal plasma concentrations of N-terminal pro-B-type natriuretic peptide in clinically healthy adult small size dogs: Effect of body weight, age, gender and breed, and reference intervals, Res Vet Sci 95(3):879-85 (2013)
8.
T. Laloë et R. Servien
Nonparametric estimation of regression level sets using kernel plug-in estimator, J. Korean Statist. Soc. 42(3), 301-311 (2013)
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9.
T. Laloë et R. Servien
The X-Alter Algorithm : A Parameter-Free Method of Unsupervised Clustering, J. Mod. App. Stat. Meth 12(1), 90-102 (2013)
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10.
Cano PM , Jamin EL , Tadrist S , Bourdaudhui P , Pean M , Debrauwer L , Oswald IP , Delaforge M and Puel O
New untargeted metabolic profiling combining mass spectrometry and isotopic labeling: application on Aspergillus fumigatus grown on wheat, Anal Chem 85 (2013) 8412-8420

-------- Publications 2012 --------


Articles
1.
Chetboul V, Daste T, Gouni V, Concordet D, Trehiou-Sechi E, Serres F, Pouchelon JL, Germain CA, Layssol-Lamour C, Lefebvre HP
Renal resistive index in 55 dogs with degenerative mitral valve disease, J Vet Intern Med 26 (1) 101-108 (2012)
2.
Domingos MC, Médaille C, Concordet D, Briend-Marchal A
Establishing bioequivalence of veterinary premixes (Type A medicated articles), J Vet Pharmacol Ther 35 Suppl 1:53-63 (2012)
3.
Domingos MC, Médaille C, Concordet D, Briend-Marchal A
Is it possible to use expired tubes for routine biochemical analysis in dogs?, Vet Clin Pathol 41(2):266-71 (2012)
4.
Collignon CM, Heiene R, Queau Y, Reynolds BS, Craig AJ, Concordet D, Harran NX, Risøen U, Balouka D, Faucher MR, Eliassen KA, Biourge V, Lefebvre HP
Comparison of pharmacokinetic variables for creatinine and iohexol in dogs with various degrees of renal function, Am J Vet Res 73(11):1841-7 (2012)

-------- Publications 2011 --------


Articles
1.
GEFFRE, A. , CONCORDET, D. , TRUMEL, C. and BRAUN, JP.
Validation of preexisting reference intervals: can the procedure be applied to canine hemostasis ?, J Vet Diagn Invest. 23 (2011) 343-347
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2.
GEFFRE, A. , CONCORDET, D. , BRAUN, J. P. and TRUMEL, C.
Reference Value Advisor: a new freeware set of macroinstructions to calculate reference intervals with Microsoft Excel, Vet Clin Pathol. 40 (2011) 107-112
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3.
LAFFONT, C. M. and CONCORDET, D.
A new exact test for the evaluation of population pharmacokinetic and/or pharmacodynamic models using random projections, Pharm Res. 28 (2011) 1948-1962
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4.
Mogicato G. , Layssol-Lamour C. , Conchou F. , Diquelou A. , Rahisson F. , Sautet J. and Concordet D.
Ultrasonographic evaluation of the adrenal glands in healthy dogs: repeatability, reproducibility, observer-dependent variability, and the effect of bodyweight, age and sex, Vet Rec 168 (2011)
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5.
BOURGES-ABELLA, N. , GEFFRE, A. , CONCORDET, D. , BRAUN, JP. and TRUMEL, C.
Canine reference intervals for the Sysmex XT-2000iV hematology analyzer, Vet Clin Pathol 40 (2011) 303-315
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-------- Publications 2010 --------


Articles
1.
Rattez, EP , REYNOLDS, B. S. , CONCORDET, D. , LAYSSOL-LAMOUR, C. , Segalen, MM. , CHETBOUL, V. and LEFEBVRE, H. P.
Within-day and between-day variability of blood pressure measurement in healthy conscious Beagle dogs using a new oscillometric device, J Vet Cardiol. 12 (2010) 35-40
2.
Schmitt, A. , Gladieff, L. , Laffont, CM. , Evrard, A. , Boyer, JC. , Lansiaux, A. , Bobin-Dubigeon, C. , Etienne-Grimaldi, MC. , Boisdron-Celle, M. Mousseau, M. Pinguet, F. Floquet, A. Billaud, EM. Durdux, C. Le Guellec, C. Mazières, J. Lafont, T. Ollivier, F. , Concordet, D. and Chatelut, E.
Factors for Hematopoietic Toxicity of Carboplatin: Refining the Targeting of Carboplatin Systemic Exposure. , J. Clin. Oncol 28 (2010) 4568-4574
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3.
Chetboul V, Tissier R, Gouni V, de Almeida V, Lefebvre HP, , Concordet D, and Jamet N, Sampedrano CC, Serres F, Pouchelon JL
Comparison of Doppler ultrasonography and high-definition oscillometry for blood pressure measurements in healthy awake dogs., Am J Vet Res. 71 (2010) 766-772
4.
Reynolds BS, , Concordet D. and Germain CA, Daste T, Boudet KG, Lefebvre HP
Breed dependency of reference intervals for plasma biochemical values in cats, J Vet Intern Med 24 (2010) 809-818
5.
D. Chafaï and D. Concordet
Confidence region for the multinomial parameter with small sample size: Reply, JASA 105, p.1632 (2010)

-------- Publications 2009 --------


Articles
1.
ANTIC, J. , LAFFONT, C. M. , CHAFAI, D. and CONCORDET, D.
Comparison of nonparametric methods in nonlinear mixed effects models, CSDA 53 (2009) 642-656
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2.
GEFFRE, A. , BRAUN, JP. , TRUMEL, C. and CONCORDET, D.
Estimation of reference intervals from small samples: an example using canine plasma creatinine, Vet Clin Pathol. 38 (2009) 477-484
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3.
GEFFRE, A. , FRIEDRICHS, K. , HARR, K. , CONCORDET, D. , TRUMEL, C. and BRAUN, J. P.
Reference values: a review, Vet Clin Pathol. 38 (2009) 288-298
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4.
CHAFAI, D. and CONCORDET, D.
A new method for the estimation of variance matrix with prescribed zeros in nonlinear mixed effects models, Stat Comput 19 (2009) 129-138
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5.
CHAFAI, D. and MALRIEU, F.
On fine properties of mixtures with respect to concentration of measure and Sobolev type inequalities , Ann. Inst. H. Poincaré accepted (2009)
6.
CHAFAI, D. and CONCORDET, D.
Confidence region for the multinomial parameter with small sample size, JASA 104 (2009) 1071-1079
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7.
CHAFAI, D. , MALRIEU, F. and PAROUX, K.
On the long time behavior of the TCP window size process , SPA accepted (2009)
8.
CONCORDET, D. , GEFFRE, A. , BRAUN, JP. and TRUMEL, C.
A new approach for the determination of reference intervals from hospital-based data, Clin Chim Acta 405 (2009) 43-48
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9.
CHAFAI, D.
Aspects of large random Markov kernels , Stochastics 81 (2009) 415-429
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-------- Publications 2008 --------


Articles
1.
CONCORDET, D. , VERGEZ, F. , TRUMEL, C. , DIQUELOU, A. , LANORE, D. , LE GARRERES, A. , PAGES, J. P. , PECHEREAU, D. , MEDAILLE, C. and BRAUN, J. P.
A multicentric retrospective study on serum/plasma urea and creatinine concentrations in dogs, Vet Clin Pathol. 37 (2008) 96-103
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2.
CHAFAI, D. and CONCORDET, D.
Explicit formulas for a continuous stochastic maturation model: Application to anticancer drug pharmacokinetics/pharmacodynamics , Stochastic Models 24 (2008) 376-400
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3.
Bakry, D. , Baudoin, F. , Bonnefont, M. and Chafai, D.
On gradient bounds for the heat kernel on the Heisenberg group , JFA 255 (2008) 1905-1938
4.
Palierne S , Mathon D , Asimus E , Concordet D , Meynaud-Collard P and Autefage A
Segmentation of the canine population in different femoral morphological groups, Res Vet Sci 85 (2008) 407-417
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-------- Publications 2007 --------


Articles
1.
FERRE, P. J. , LIAUBET, L. , CONCORDET, D. , SANCRISTOBAL, M. , URO-COSTE, E. , TOSSER-KLOPP, G. , BONNET, A. , TOUTAIN, P. L. , HATEY, F. and LEFEBVRE, H. P.
Longitudinal analysis of gene expression in porcine skeletal muscle after post-injection local injury., Pharmaceutical Research 24 (2007) 1480-1489
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2.
CHAFAI, D. and CONCORDET, D.
On the strong consistency of asymptotic M-estimators, JSPI 137 (2007) 2774-2783
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Livres ou chapitres
1.
CHAFAI, D. and BERCU, B.
Modelisation stochastique et simulation, Mathematiques Appliquees pour le Master (2007)

-------- Publications 2006 --------


Articles
1.
CHAFAI, D. and LOUBES, J.M.
On nonparametric maximum likelihood for a class of stochastic inverse problems, Statistics and Probability Letters 76 (2006) 1225-1237
2.
REGNIER, A. , LEMAGNE, C. , PONCHET, A. , CAZALOT, G. , CONCORDET, D. and GELATT, K. N.
Ocular effects of topical 0.03% bimatoprost solution in normotensive feline eyes, Veterinary Ophthalmology 9 (2006) 39-43
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3.
CHAFAI, D.
Binomial-Poisson entropic inequalities and the M/M/Infinity queue, ESAIM PS 10 (2006) 317-339

Revues
1.
CONCORDET, D.
Quatre erreurs d'interprétation statistique des essais cliniques post-AMM, Bulletin des GTV 37, 63-65. (2006)
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-------- Publications 2005 --------


Articles
1.
CHETBOUL, V. , SAMPEDRANO, C. C. , CONCORDET, D. , TISSIER, R. , LAMOUR, T. , GINESTA, J. , GOUNI, V. , NICOLLE, A. P. , POUCHELON, J. L. and LEFEBVRE, H. P.
Use of quantitative two-dimensional color tissue Doppler imaging for assessment of left ventricular radial and longitudinal myocardial velocities in dogs, American Journal of Veterinary Research 66 (2005) 953-61
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2.
CHETBOUL, V. , SAMPEDRANO, C. C. , GOUNI, V. , CONCORDET, D. , LAMOUR, T. , GINESTA, J. , NICOLLE, A. P. , POUCHELON, J. L. and LEFEBVRE, H. P.
Quantitative assessment of regional right ventricular myocardial velocities in awake dogs by Doppler tissue imaging: repeatability, reproducibility, effect of body weight and breed, and comparison with left ventricular myocardial velocities, Journal of Veterinary Internal Medicine 19 (2005) 837-44
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3.
CHETBOUL, V. , TIDHOLM, A. , NICOLLE, A. , SAMPEDRANO, C. C. , GOUNI, V. , POUCHELON, J. L. , LEFEBVRE, H. P. and CONCORDET, D.
Effects of animal position and number of repeated measurements on selected two-dimensional and M-mode echocardiographic variables in healthy dogs, Journal of the American Veterinary Medical Association 227 (2005) 743-7
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4.
CREVIER-DENOIX,N. , POURCELOT,P. , ERLINGER,D. , CONCORDET,D. , LAGACHE,C. , RICARD,A. , TAVERNIER,L. and DENOIX,J. M.
Comparison of the Comformation of 20 International Level and the 20 Low Level Jumping Horses Using a 3-D Video Morphometric Measurement Method, Journal of Veterinary Medicine Series C: Anatomia, Histologia, Embryologia 34 (2005) 13-13
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5.
LEFEBVRE, H. P. and CONCORDET, D.
Validation of quantitative endpoints for clinical trials: An emerging challenge, Journal of Veterinary Cardiology 7 (2005) 5-7
6.
MARTIN, P. G. , LASSERRE, F. , CALLEJA, C. , VAN ES, A. , ROULET, A. , CONCORDET, D. , CANTIELLO, M. , BARNOUIN, R. , GAUTHIER, B. and PINEAU, T.
Transcriptional modulations by RXR agonists are only partially subordinated to PPARalpha signaling and attest additional, organ-specific, molecular cross-talks, Gene Expression 12 (2005) 177-92
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7.
MONNEREAU, L. , CARRETERO, A. , BERGES, S. , NAVARRO, M. , LEONARD, M. , LYAZRHI, F. , SAUTET, J. and RUBERTE, J.
Mophometric study of the aortic arch and its major branches in rat fetuses on the 21st day of gestation, Anatomy and Embryology (Berlin) 209 (2005) 357-69
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-------- Publications 2004 --------


Articles
1.
CHETBOUL, V. , ATHANASSIADIS, N. , CARLOS, C. , NICOLLE, A. , ZILBERSTEIN, L. , POUCHELON, J. L. , LEFEBVRE, H. P. and CONCORDET, D.
Assessment of repeatability, reproducibility, and effect of anesthesia on determination of radial and longitudinal left ventricular velocities via tissue Doppler imaging in dogs, American Journal of Veterinary Research 65 (2004) 909-15
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2.
CHETBOUL, V. , ATHANASSIADIS, N. , CARLOS, C. , NICOLLE, A. P. , TISSIER, R. , POUCHELON, J. L. , CONCORDET, D. and LEFEBVRE, H. P.
Quantification, repeatability, and reproducibility of feline radial and longitudinal left ventricular velocities by tissue Doppler imaging, American Journal of Veterinary Research 65 (2004) 566-72
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3.
CHETBOUL, V. , ATHANASSIADIS, N. , CONCORDET, D. , NICOLLE, A. , TESSIER, D. , CASTAGNET, M. , POUCHELON, J. L. and LEFEBVRE, H. P.
Observer-dependent variability of quantitative clinical endpoints: the example of canine echocardiography, Journal of Veterinary Pharmacology and Therapeutics 27 (2004) 49-56
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4.
MEDAILLE, C. , TRUMEL, C. , CONCORDET, D. , VERGEZ, F. and BRAUN, J. P.
Comparison of plasma/serum urea and creatinine concentrations in the dog: a 5-year retrospective study in a commercial veterinary clinical pathology laboratory, Journal of Veterinary Medical Series A-Physiology Pathology Clinical Medicine 51 (2004) 119-23
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-------- Publications 2003 --------


Articles
1.
ANE, C. and CONCORDET, D.
Population pharmacokinetics/pharmacodynamics relationships of an anticancer drug, Statistics in Medicine 22 (2003) 833-46
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2.
CHETBOUL, V. , CONCORDET, D. , POUCHELON, J. L. , ATHANASSIADIS, N. , MULLER, C. , BENIGNI, L. , MUNARI, A. C. and LEFEBVRE, H. P.
Effects of inter- and intra-observer variability on echocardiographic measurements in awake cats, Journal of Veterinary Medicine A - 50 (2003) 326-331
3.
REGNIER, A. , CONCORDET, D. , SCHNEIDER, M. , BOISRAME, B. and TOUTAIN, P. L.
Population pharmacokinetics of marbofloxacin in the aqueous humour after intravenous administration in dogs, American Journal of Veterinary Research 64 (2003) 889-893

-------- Publications 2002 --------


Articles
1.
CHANOIT, G. P. , CONCORDET, D. , LEFEBVRE, H. P. , ORCEL, K. and BRAUN, J. P.
Exercise does not induce major changes in plasma muscle enzymes, creatinine, glucose and total proteins concentrations in untrained beagle dogs, Journal of Veterinary Medicine 49 (2002) 222-224
2.
D. CONCORDET and O. G. NUNEZ
A simulated pseudo-maximum likelihood estimator for nonlinear mixed models, Computational Statistics and Data Analysis 39 (2002) 187-201
3.
PICARD-HAGEN, N. , SOURBE, O. , LYAZRHI, F. , COUPET, H. , HENNEQUIN, M. , JACOB, H. and BERTHELOT, X.
Effect of precocious collection on semen output and quality in young Holstein bulls, Theriogenology 57 (2002) 1511-22
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4.
WATSON, A. D. , LEFEBVRE, H. P. , CONCORDET, D. , LAROUTE, V. , FERRE, J. P. , BRAUN, J. P. , CONCHOU, F. and TOUTAIN, P. L.
Plasma exogenous creatinine clearance test in dogs: comparison with other methods and proposed limited sampling strategy, Journal of Veterinary Internal Medicine 16 (2002) 22-33.
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-------- Publications 2001 --------


Articles
1.
FERRE, P. J. , CONCORDET, D. , LAROUTE, V. , CHANOIT, G. P. , FERRE, J. P. , MANESSE, M. and LEFEBVRE, H. P.
Comparison of ultrasonography and pharmacokinetic analysis of creatine kinase release for quantitative assessment of postinjection muscle damage in sheep, American Journal of Veterinary Research 62 (2001) 1698-705.
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2.
HAY, M. , ORGEUR, P. , LEVY, F. , LE DIVIDICH, J. , CONCORDET, D. , NOWAK, R. , SCHAAL, B. and MORMEDE, P.
Neuroendocrine consequences of very early weaning in swine, Physiology and Behavior 72 (2001) 263-269
3.
LEFEBVRE, H. P. , FERRE, J. P. , WATSON, A. D. , BROWN, C. A. , SERTHELON, J. P. , LAROUTE, V. , CONCORDET, D. and TOUTAIN, P. L.
Small bowel motility and colonic transit are altered in dogs with moderate renal failure, American Journal of Physiology 281 (2001) R230-8.
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-------- Publications 2000 --------


Articles
1.
BRAUN, J. P. , CONCORDET, D. , LYAZRHI, F. , LEFEBVRE, H. P. and TOUTAIN, P. L..
Overestimation of the predictive value of positives by the usual calculations of the specificity of diagnostic tests, Vet Res Commun. 24 (2000) 17-24
2.
CONCORDET, D. and NUNEZ, O. G.
Calibration for nonlinear mixed effects models: an application to the withdrawal time prediction, Biometrics 56 (2000) 1040-6
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More is coming soon (research papers, software, ...). Please be patient!